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Compared with mouse thymocytes, mouse ES cells include higher levels of total genomic H3K4me3 and have larger H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In settlement with this, world decreases in H3K4me3 ranges occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells forty seven As well as, there are dynamic modifications in H3K4me3 profiles at particular units of genes during ES cell differentiation.

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